Clear platelets trial

The factorial design also assessed the additional effect of eptifibatide on top of the two doses of clopidogrel. While the study showed a mg loading dose of clopidogrel had greater platelet inhibition than a mg loading dose, the greatest benefit was observed with the addition of eptifibatide to either dose of clopidogrel. The difference was likely due to the timing of the clopidogrel administration, which was a median of 7. Circulation ; Description: The goal of the study was to evaluate use of eptifibatide and clopidogrel on platelet inhibition and myocardial necrosis among patients undergoing elective stenting.

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Recruitment status was: Recruiting First Posted : August 30, Last Update Posted : August 30, Study Description. The purpose of this study is to compare levels of clot formation platelet aggregation , markers of heart muscle damage, and inflammation in two groups undergoing percutaneous coronary stent implantation.

Clinical outcomes will be determined up to one year after enrollment. Detailed Description:. Drug Information available for: Bivalirudin Eptifibatide.

FDA Resources. Arms and Interventions. Outcome Measures. Secondary Outcome Measures : Compare the release of myocardial necrosis and inflammatory markers Measure platelet reactivity with conventional light transmittance aggregometry and thrombelastography Assess in-hospital 30 day, and 1 year clinical outcomes. Platelet count on day 1 postop and on the last measurement prior to ICU discharge, death or day 28, whichever occurs first.

Fibrinogen concentration, on day 1 postop and on the last measurement prior to ICU discharge, death or day 28, whichever occurs first. Incidence of potential complications of DMSO preservative used in cryopreserved platelets such as nausea, headache,tachyacrdia, bradycardia, hypertension. Duration of mechanical ventilation in the first 90 postoperative days for the index admission. Total estimated healthcare cost, incorporating the cost of provision of cryopreserved or liquid-stored platelets.

Eligibility Criteria. Known allergy to dimethylsulphoxide DMSO Planned presence of an arterial line and central venous catheter for less than 12 hours postoperatively. Known objection to receipt of human blood components The treating physician believes it is not in the best interest of the patient to be randomised in this trial Previous enrolment during this admission in a clinical trial of a medication or technique thought to influence bleeding, with the exception of any trial of aspirin i.

Previous enrolment in this study. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials. More Information. Layout table for additional information Studies a U. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Surgical Blood Loss Hemorrhage. Biological: Cryopreserved platelets Biological: Liquid-stored platelets. Phase 3. Study Type :. Finally, baseline characteristics were fairly balanced between groups in reviewing table 1, not sure I am really seeing an unfair balance.

In the end, it is an interesting study, and should give us some food for thought as it is currently the strongest level of evidence available. I think the next step would be to see an external validation RCT. Save my name, email, and website in this browser for the next time I comment. Time limit is exhausted. All rights reserved. Disclaimer Website by Innov8 Place. June 15, The mechanism for this is not exactly clear from this study, but some potential mechanisms include: Some patients may have had hemorrhagic transformation of infarction rather than intracerebral hemorrhage.

Collateral perfusion around the intracerebral hemorrhage could have been impaired resulting in cerebral ischemia. References: Baharoglu MI et al.